From AAL to ambient assisted rehabilitation: a research pilot protocol based on smart objects and biofeedback

AbstractThe progressive miniaturization of electronic devices and their exponential increase in processing, storage and transmission capabilities, represent key factors of the current digital transformation, also sustaining the great development of Ambient Assisted Living (AAL) and the Internet of Things. Although most of the investigations in the recent years focused on remote monitoring and diagnostics, rehabilitation too could be positively affected by the widespread integrated use of these devices. Smart Objects in particular may be among the enablers to new quantitative approaches. In this paper, we present a proof-of-concept and some preliminary results of an innovative pediatric rehabilitation protocol based on Smart Objects and biofeedback, which we administered to a sample of children with unilateral cerebral palsy. The novelty of the approach mainly consists in placing the sensing device into a common toy (a ball in our protocol) and using the information measured by the device to administer multimedia-enriched type of exercises, more engaging if compared to the usual rehabilitation activities used in clinical settings. We also introduce a couple of performance indexes, which could be helpful for a quantitative continuous evaluation of movements during the exercises. Even if the number of children involved and sessions performed are not suitable to assess any change in the subjects' abilities, nor to derive solid statistical inferences, the novel approach resulted very engaging and enjoyable by all the children participating in the study. Moreover, given the almost non-existent literature on the use of Smart Objects in pediatric rehabilitation, the few qualitative/quantitative results here reported may promote the scientific and clinical discussion regarding AAL solutions in a "Computer Assisted Rehabilitation" perspective, towards what can be defined "Pediatric Rehabilitation 2.0"

Applications of Robotics for Autism Spectrum Disorder: a Scoping Review

Robotic therapies are receiving growing interest in the autism field, especially for the improvement of social skills of children, enhancing traditional human interventions. In this work, we conduct a scoping review of the literature in robotics for autism, providing the largest review on this field from the last five years. Our work underlines the need to better characterize participants and to increase the sample size. It is also important to develop homogeneous training protocols to analyse and compare the results. Nevertheless, 7 out of the 10 Randomized control trials reported a significant impact of robotic therapy. Overall, robot autonomy, adaptability and personalization as well as more standardized outcome measures were pointed as the most critical issues to address in future research

A Mathematical Model of Immune Competition Related to Cancer Dynamics

International audienceThis paper deals with the qualitative analysis of a model describing the competition among cell populations each of them expressing a peculiar cooperating and organizing behaviour. The mathematical framework in which the model has been developed is the kinetic theory for active particles. The main result of this paper is concerned with the analysis of the asymptotic behavior of the solutions. We prove that, if we are in the case when the only equilibrium solution if the trivial one, the system evolves in such a way that the immune system, after being activated, goes back towards a physiological situation while the tumor cells evolve as a sort of progressing travelling waves, characterizing a typical equilibrium/latent situation

On the kinetic theory for active particles: A model for tumor-immune system competition

This paper deals with the qualitative analysis of a model describing the competition between tumor and immune cells. Such competition is characterized by proliferation-destruction phenomena and the interacting entities are characterized by a microscopic state which is modified by interactions. The model also includes the description of the natural trend of immune cells to reach a healthy or sentinel level, even when they have been involved in the competition with the tumor cells. The model is developed in the mathematical framework of the kinetic theory for active particles

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services